Project Grants

A list of the project grants we are currently funding is given below. Each project page gives a simple summary of the project and its ultimate aims, as well as a more detailed description from the researchers themselves.

Health benefits of non-invasive ventilation (NIV) in MND

Awarded to: Dr C Young, Walton Centre for Neurology & Neurosurgery, Liverpool (Young/Mar07/6026)

Integrated analysis of axonal transport in vitro and in vivo

Awarded to: Dr G Schiavo & Dr L Bilsland, Cancer Research UK, Dr L Greensmith, Institute of Neurology, University College London (Schiavo/Apr06/6016)

Investigation of RNA editing in intron 7 of EAAT2 and its relevance to MND

Awarded to: Dr A Makoff & Dr R Flomen, Institute of Psychiatry, King's College London (Makoff/Mar07/6029)

Investigations of compensatory synaptic plasticity in MND

Awarded to: Dr A Pullen, Institute of Neurology, University College London (Pullen/Apr06/6014)

Living with MND: an internet resource for people affected by MND, their families and carers

Awarded to: Ms S Ziebland, Dr C Dumelow & Prof C Jenkinson, University of Oxford

Reciprocal interactions between Shwann cells and motor neurons in mSOD-1mediated disease

Awarded to: Prof K Davies, University of Oxford (Davies/Jul06/6018)

Regulation of motor nerve terminal degeneration by neuromuscular activity in the SOD1 mouse model of MND

Awarded to: Prof R Ribchester, University of Edinburgh (Ribchester/Mar07/6025)

The roles of calcium-permeable AMPA receptors and RNA editing in MND

Awarded to: Dr L Keegan, University of Edinburgh & Dr P Heath, University of Sheffield (Keegan/Mar07/6028)

Unravelling the role of PHDs in MND

Awarded to: Prof P Carmeliet, University of Leuven (Carmeliet/Feb07/6024)

X-ray studies on the structure of mutant SOD1

Awarded to: Prof S Hasnain & Dr R Strange, CCLRC Daresbury Laboratory (Hasnain/Apr06/6015)

Protection of motor neurons by dietary flavonoids

Awarded to: Dr R Williams, Dr M Rattray, King's College London (Williams/Oct07/6030)

Understanding patient choices for care in MND: a population study

Awarded to: Dr L Goldstein, Institute of Psychiatry, King's College London (Goldstein/Jun07/6334)

Disease biomarkers in a MND mouse model and their translational potential

Awarded to: Dr A Malspina, Queen Mary, University of London (Malaspina/Apr08/6039)

Detecting genetic loci for MND using homozygosity mapping

Awarded to:Dr R Orrell & Prof J Hardy, Institute of Neurology, Unveristiy College London (Orrell/Apr08/6040)

The chick embryo as a model system for ALS

Awarded to: Dr A Al-Chalabi & Prof C Shaw, Institute of Psychiatry, King’s College London (Al-Chalabi/Apr08/6041)

Evaluation of the impact of a cough assist mechanical exsufflator device in patients with MND

Awarded to: Prof P Shaw, University of Sheffield (Shaw/Apr08/6335)

Changes in nerve excitability during disease progression in animal models of MND

Awarded to: Dr L Greensmith & Prof H Bostock, Institute of Neurology, University College London (Greensmith/Apr08/6038)

Mechanisms underlying axonal transport defects in MND

Awarded to: Dr A Grierson, University of Sheffield & Dr K de Vos & Prof C Miller, Institute of Psychiatry, King’s College London (Grierson/Apr08/6042)