Reciprocal interactions between Schwann cells and motor neurons in mutant SOD-1 mediated disease

Description:

What this research means to you: Evidence suggests that cells other than motor neurones may contribute to MND; this project examines the role of nerve support cells (known as Schwann cells) in the disease. The results should provide new insights into MND disease mechanisms and identify alternative avenues for treatment.

The researcher explains in more detail: Schwann cells normally insulate nerves and provide protective factors essential for motor neurone survival and recovery after injury or disease. These protective elements may be lacking in MND due to changes in Schwann cell function, contributing to motor neurone degeneration. This study aims to investigate whether Schwann cells from mice that model MND are deficient in particular protective factors before and after symptoms appear. Schwann cells and motor neurones will be isolated from the mice and tested for interactions. Understanding the relationship between Schwann cells and motor neurone degeneration should provide novel insights into MND disease mechanisms and identify new strategies for treatment.

Prof Davies' institution web page