MAGNET Platform Trial

What is the MAGNET Platform Trial?

'MAGNET' (Multi-arm, Adaptive, Group-sequential trial NETwork) is the first international platform trial focused on finding effective treatments for MND. It will test multiple treatments simultaneously.

A large advantage of this multi-arm design is that it gives a higher chance for people to be randomised into the treatment arms rather than the placebo arm. In the future, new candidate drugs can be added to the study – giving people an even better chance of being randomised to take a potential treatment.

A computer model determines whether you are eligible to participate, based on your disease characteristics such as age, symptom duration and lung function. The computer makes a forecast of the expected disease pattern. By using this forecast, more than 75% of the patients will be able to participate instead of the 25 – 40% when using classical criteria.

What does the drug do?

The MAGNET trial currently consists of one sub-study to test the efficacy of lithium carbonate, called the PRELUDE trial. Lithium carbonate has a long history as a treatment for mood disorders and several studies have highlighted the protective effects of Lithium carbonate in the brain.

This trial will look at the use of lithium carbonate in people living with MND who have the UNC13a mutation. This mutation in the UNC13a gene is known to be associated with the prognosis and symptoms of ALS. Analysis has shown that participants carrying the UNC13a mutation may respond better to Lithium Carbonate than those who do not carry the mutation. Lithium carbonate has already been shown to be safe in humans. You can find out more about the trial here.

The trial is currently in preparation in the UK. We will update this page as soon as recruitment opens and the UK sites are announced.

Latest News

March 2022 - TRICALS announces that the MAGNET trial has open to recruitment in Europe. You can read more here.

July 2020 - European Medicines Agency (EMA) endorses the MAGNET trial

Resources

Want to find out more about the MAGNET Platform Trial? Check out the resources below:

Website:

https://www.tricals.org/en

Find out more about Lithium carbonate here:

Blogs:

Lithium revisited: Is there a baby in the bathwater?

Last updated: 01/08/2022