Role of immune-related autophagy and inflammation in C9MND/FTD

To establish the role of C9orf72 in immune-related autophagy and related inflammatory responses, and to determine its possible involvement in C9MND/FTD

Kurt

Lead Investigator: Professor Kurt De Vos

Lead Institution: Sheffield Institute for Translational Neuroscience

MND Association Funding: £226,197*

Funding dates: September 2018 - July 2023

*Supported by the Astor Foundation and The Mackintosh Foundation

About the project

This project will investigate MND caused by a C9orf72 defective gene which results in inflammation when the waste removal system of the cell, a process called autophagy, is not working properly and causes a build-up of toxic waste. The researchers will test a number of drugs that increase the autophagy process using zebrafish and in cells donated by patients, to see if these potential treatments reduce inflammation which it is hoped might benefit MND patients.

What does this mean for people living with MND?

The project will test a number of drugs that increase the autophagy process to see if they are effective at reducing inflammation. If this is successful, the next step would be to test these drugs further to see if they or similar ones could be used as a treatment for MND.

Resources 

Want to find out more about the project? Check out the resources below:

Blogs:

How faulty proteins disrupt waste recycling and disposal inside nerve cells - MND Research Blog

Project code: 862-791