TDP-43 and p62 in MND-FTD: when a molecular handshake goes wrong

To understand more about the interaction between TDP-43 and p62 and the effects it may have on the function of motor neurons.

Dan Scott May 2021 717x550

Lead Investigator: Dr Daniel Scott

Lead Institution: University of Nottingham

MND Association Funding: £254,116* Junior Non-Clinical Fellowship

Funding dates: August 2019 - January 2023

* Supported by The Lady Edith Wolfson Fellowship Programme and the Payne-Gallwey Charitable trust and the UK Governemtn BEIS/DH Medical Research Charity Support Fund

About the project

A recently discovered interaction or ‘molecular handshake’ between TDP-43 protein (that builds-up in and is toxic to diseased motor neurons) and another protein called p62 (which controls key cellular ‘waste-disposal’ systems) could be harmful in affected individuals. The purpose of this fellowship is to understand the effect this interaction might have on motor neurons and to investigate the utility of targeting p62 to prevent the build-up of toxic TDP-43 as a potential therapeutic strategy in MND.

What does this mean for people living with MND?

The project will also investigate whether targeting p62 can help prevent the accumulation of TDP-43, which may lead to the identification of a new potential therapeutic target.


Want to find out more about the project? Check out the resources below:


Driving MND Research through our Junior Non-Clinical Fellowship Programme - MND Research Blog


Our Fellows | MND Association

I was absolutely humbled to be awarded an MND Association junior non-clinical fellowship, and to have the opportunity to work every day to drive MND research forward. Importantly, this award has allowed me to transition to lead my own research team, principally dedicated to understanding, and ultimately targeting MND

Project code: 970-799