Models of MND

One way in which to understand the function of a gene and how this goes wrong in a disease, or the impact of a biochemical pathway malfunctioning, is to use a model. This might be in mice or isolated cells in a dish. These projects aim to develop new and better models of MND to better understand the causes of MND. An asterisk (‘*’) next to a title marks the research projects that directly involve animals.

Biomedical projects

Understanding the role of FUS in a mouse model of MND (822-791)*
Developing a drug screen using neurones from a TDP-43 mouse model (831-791)*
Using DNA Bank samples to create iPSC models of MND (80-970-797)
Creating a C9ORF72 mouse model of MND (841-791)*
Creating a ‘protein-only’ C9ORF72 mouse model (834-791)*
Understanding FUS to help develop future therapies in the mouse (874-792) *
Targeting disease pathways of juvenile MND using mice models and iPS cells (851-791) *
Observing MND-related changes in the brain of mice with TDP-43 protein (849-791) *
A Drosophila model for an Annexin gene causing ALS (855-791) *

PhD studentships

Investigating C9ORF72 and TDP-43 proteins in a fruitfly model of MND (868-792)*
Development of a C9ORF72 zebrafish model (875-792) *
Humanizing TDP-43 in the mouse (876-792) *
Identifying common points of neuronal dysfunction in the MND-FTD spectrum using fruitfly and iPSC models (884-792) *
Exploring mechanisms causing TDP-43 depositions in a fruitfly model (890-792) *
Investigating changes in miR-9 and their effect on autophagy (887-792)

Last updated: 13 October 2017

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