Dazucorilant

What does the drug do?

Increased levels of cortisol have been seen in people living with MND. High levels of cortisol can increase inflammation and be toxic to nerve cells, which are associated with MND. Dazucorilant blocks the glucocorticoid receptor, which normally binds to cortisol. Blocking cortisol from binding is thought to limit the consequences of increased cortisol exposure and potentially help slow disease progression. In pre-clinical animal models, Dazucorilant was found to improve motor performance, reduce neuroinflammation and muscular atrophy. 

Phase 2 - DAZALS

Current status: Collecting data

DAZALS aims to investigate the safety and efficacy of Dazucorilant in a double blind, placebo control trial where participants will either receive the treatment or placebo (in a 1:1 ratio) for 24-weeks. 249 participants were recruited into the trial. The trial is also investigating different doses of Dazucorilant, so those who were enrolled in the treatment group received either 150 mg or 300 mg (in a 1:1 ratio). Participants who complete the trial will be able to continue into the open-label part of the trial, where all participants will have the option to receive the treatment for 24-weeks. Find out more on the MND Clinical Studies Group website or on clinicaltrials.gov.

Last updated: 15/04/2024