Identifying microRNAs linked to MND and exploring whether targeting these microRNAs can protect motor neurons in models of MND.
Principal Investigator: Professor Marco Milanese
Lead Institution: University of Genoa and University of Sheffield
MND Association Funding: £290,125
Funding dates: February 2026 - January 2029
About the project
Recent research has shown that small biological molecules called microRNAs (miRNAs), which help to control the expression of different genes, are changed in MND. These molecules can be released from cells and detected in the blood, and ongoing research is exploring their potential as biomarkers for MND. As well as being potential biomarkers, miRNAs are thought to be directly involved in disease processes and therefore might be able to be targeted therapeutically. In this study, the researchers will use AI-driven analyses of existing data to identify which miRNAs are most closely linked to disease processes in MND. They will then confirm whether these specific miRNAs are toxic to motor neurons using highly specialised ‘nanocapsules’ that can deliver the molecules directly into the brain without causing a damaging immune response. The studies will initially be carried out using cell models of MND, then will later be carried out in a mouse model of MND. Alongside this, the researchers will test anti-miRNA molecules, which work by silencing the harmful miRNAs, in the aim of protecting motor neurons.
What could this mean for MND research?
It is hoped that the study will both confirm the species of miRNA that damage motor neurons and also provide the foundation for future studies that can deliver potential therapies whilst minimising side effects.
Project code: 2481-791
