Here you can find more information about the projects we are funding that are developing the treatment pipeline. Click on a project to find out more information and what the project means to a person living with MND.
These projects aim to turn the most promising scientific discoveries into potential new treatments. New treatments that have been proven safe and effective by all other methods are then carefully tested in people.
Exploring whether changes to RNA in models of MND can be reversed with different drug combinations
Dr Bhuvanish Selvaraj
Gene activity in MND: from disease mechanisms to treatment opportunity
Dr Carlo Rinaldi
Development of RAR class ligands for treatment of MND
Prof Peter McCaffery
A Dual Gene Therapy Approach for C9orf72-related MND
Dr Christopher Webster
Improving the safety and specificity of a new gene therapy system for MND
Dr Oscar Wilkins
Investigating membrane lipid rafts as a therapeutic target in ALS
Dr Tobias Moll
The role of TBK1-dependant immune signalling pathways in MND
Dr Valeria Gerbino
Studying a multi-microRNA-targeted therapy approach in pre-clinical models of MND
Prof Marco Milanese
Assessing the dosing and effectiveness of compounds targeting TDP-43 aggregation in MND
Dr Mark Baker
Development of new compounds to help target faulty SOD1 protein as a potential treatment of MND
Prof Samar Hasnain