Here you can find more information about the projects we are funding that are understanding clinical progression. Click on a project to find out more information and what the project means to a person living with MND.
Developing a detailed understanding of how the disease manifests and progresses in humans to ensure that fundamental laboratory research can be clearly linked to the ‘real world’ events occurring in people with MND.
![](https://www.mndassociation.org/sites/default/files/styles/cards/public/2023-08/Dan%20Baxter-Beard%20headshot.jpg?itok=iquJUfyB)
Developing Motor Unit MRI as a diagnostic tool for MND
Prof Andrew Blamire/Dan Baxter-Beard
![](https://www.mndassociation.org/sites/default/files/styles/cards/public/2023-01/Ayodeji%20Ijishakin_1.jpg?itok=0DzQpAgi)
Neuroimaging and neurochemical biomarkers of brain ageing in MND
Dr James Cole/Ayodeji Ijishakin
![](https://www.mndassociation.org/sites/default/files/styles/cards/public/2023-01/Roisin%20McMakin.jpg?itok=9ry1Q5aP)
Development of MND prognostic biomarkers based on brain function
Dr Roisin McMackin
![](https://www.mndassociation.org/sites/default/files/styles/cards/public/2023-04/Al%20Khleifat%2C%20Ahmad-%20CONSENTED.png?itok=MXPGwEfE)
Using machine learning to find ALS and FTD sub-groups
Dr Ahmad Al Khleifat
![](https://www.mndassociation.org/sites/default/files/styles/cards/public/2023-04/DSC_5602.jpg?itok=KXJOzVAl)
Developing a home-based stimulation-free motor unit number estimate in MND
Dr James Bashford/Judith Bilgorai
![](https://www.mndassociation.org/sites/default/files/styles/cards/public/2023-04/MNDA_Matthew%20Nolan_RB_28%20Jan%202019_171.jpg?itok=L2H26qR9)
Identification of non-coding RNA biomarkers for MND
Prof Majid Hafezparast
![](https://www.mndassociation.org/sites/default/files/styles/cards/public/2023-04/Apple%20watch%20%282%29.jpg?itok=iM8mgT6o)
Developing remote monitoring tools for assessing disease progression in MND
Dr Emma Hodson-Tole/Nina Mitic
![](https://www.mndassociation.org/sites/default/files/styles/cards/public/2023-04/MNDA_Sheffield%20Sitran_Dec%202019_RB_026.jpg?itok=O0FcPqxQ)
Investigating individualised effects of low-dose interleukin-2 throughout the MIROCALS Clinical Trial
Prof Janine Kirby
![](https://www.mndassociation.org/sites/default/files/styles/cards/public/2023-04/Lara%20McManus%20cropped.jpg?itok=uNmKzVFL)
Investigating connectivity between the brain and muscle in MND
Dr Lara McManus
![](https://www.mndassociation.org/sites/default/files/styles/cards/public/2023-04/RSaleeb_Headshot.jpeg?itok=DqgUCJZs)
Characterising TDP-43 protein aggregates to identify biomarkers of MND
Dr Rebecca Saleeb
![](https://www.mndassociation.org/sites/default/files/styles/cards/public/2023-04/Timothy%20Tree%20photo%20Feb%202023%20-%20cropped.jpg?itok=uX0i9tGR)
Profiling Immune Responses to Low-Dose IL-2 in MND
Prof Timothy Tree
Investigating the export of micoRNAs in extracellular vesicles in FUS MND and FTD
Professor Rob Layfield
![](https://www.mndassociation.org/sites/default/files/styles/cards/public/2023-01/Dr%20Alex%20Thompson.png?itok=JT5Ab7ij)
Defining the relationship between lipids, statins and the risk of sporadic and familial MND
Dr Alexander Thompson
![](https://www.mndassociation.org/sites/default/files/styles/cards/public/2024-07/David%20Lester%20Headshot%20website.jpg?itok=vMxIx8Cp)
Classifying MND based on biochemical signatures
Dr David Lester