Modelling the cold stress response in astrocytes to explore whether it makes astrocytes more supportive towards motor neurons in MND.
Principal Investigator: Professor Rob Layfield
Researcher: Dr Katherine White
Lead Institution: University of Nottingham
MND Association Funding: £196,611
Funding dates: January 2026 - December 2027
About the project
Previous research has shown that reducing the temperature of cells switches on a ‘cold stress’ response that could be protective to neurons. The mechanism of protection appears to work through increased production of a protein called RBM3, and evidence suggests that artificial activation of this protein without cooling can protect neurons in some models of neurodegenerative diseases. Current research into RBM3 is focussed on its effects in motor neurons. However, RBM3 protein is also present in cells called astrocytes, whose role is to provide support for motor neurons. In this project, the researchers will explore the effect of increasing levels of RBM3 in astrocytes, and whether this change makes the astrocytes better at supporting and protecting motor neurons in MND.
What could this mean for MND research?
Modulation of RMB3 is being explored as a therapeutic option for other neurodegenerative diseases. This study will provide evidence for its therapeutic potential in MND and also, importantly, whether astrocytes might be the right cells to target. Increasing RBM3 levels in astrocytes might help them to become better at supporting motor neurons, which may help the neurons to survive for longer and potentially slow the progression of MND.
Project code: 2483-791