Increasing our understanding of the role of Annexin A11 gene changes in MND.
Principal Investigator: Dr Bradley Smith
Lead Institution: King's College London
MND Association Funding: £99,527
Funding dates: April 2025 - March 2026
About the project
Changes in several genes have been linked to the development and progression of MND. Previous research has found that changes in a gene called Annexin A11 are linked to MND and have been seen in some people with the disease. The researchers have used zebrafish models of MND to uncover that changes in Annexin A11 cause defects in the nucleus (control centre) of the neurons. These defects were also seen in post-mortem tissue from people who had changes in these genes. This project aims to use mouse models of Annexin A11 MND to find out more about the effects of the changes and how they lead to defects in the nucleus of neurons. The researchers also want to discover whether changes in the gene cause problems with communication between neurons and muscles and how this contributes to damage in MND.
What could this mean for MND research?
This research could lead to the discovery of new targets for therapy development and increase current understanding of the role of changes in Annexin A11 in MND.
Project code: 2390-791
