Improving diagnosis and classification of MND by using iron levels as a biomarker for oxidative MND.
Non-Clinical Fellow: Dr Holly Spence
Lead Institution: University of Aberdeen
MND Association Funding: £343,487
Funding dates: February 2026 - January 2029
About the project
Research suggests that there are different subtypes of MND, but being able to identify these different subtypes is challenging. One subtype is called oxidative MND, and is thought to be present in around 60% of people with MND. This research, led by Dr Holly Spence, is investigating how ferritin, which is a specific form of iron stored in the body, can be measured by MRI and used to identify and group different types of MND. The researchers will explore how ferritin levels can be used alongside protein and blood-based markers to detect oxidative MND.
What could this mean for MND research?
This project aims to identify a combination of MRI and fluid biomarkers for oxidative MND, to enable earlier and more targeted detection and treatment of this type of MND. This could then help to facilitate more personalised therapeutic approaches for people with oxidative MND.
Project code: 2518-799