The Lady Edith Wolfson Fellowship Programme attracts and develops the careers of outstanding young Clinical and Non-Clinical researchers in order to create the future scientific leaders in the field of MND Research. Find out more about our current fellows below.
Clinical Research Fellowships
The first Clinical Fellowship was awarded to Professor Martin Turner (who was Dr Martin Turner at the time) from the University of Oxford in 2008. The Clinical Fellowships are funded in a partnership with the Medical Research Council (MRC).
Dr Mehta, a neurology registrar from Oxford, is undertaking his PhD at the University of Edinburgh. His project will examine the C9orf72 genetic mutation and use patient-derived stem cells and gene editing to better understand the molecular mechanisms underlying MND.
August 2017 - January 2021
Dr Patani’s lab will use human induced pluripotent stem cells (iPSCs) to generate neuronal and glial cells from patients with ALS and healthy volunteers, to work out the earliest molecular events of the disease. Rickie's group specifically focuses on three main areas: i) how abnormalities in RNA transcript structure lead to abnormal RNA-protein interactions to cause ALS; ii) how glial cells of the brain – known as astrocytes – contribute to motor neuron degeneration and iii) how cellular ageing interfaces with the disease process.
March 2019 - February 2024
TDP-43 is a protein important for the specific transport of RNA to different locations in the axons and in the response of cells to stress and damage. This project will combine novel mouse models and patient cell lines to investigate how TDP-43 impacts the response of motor neurons to damage in the axons, and the relevance of this response pathway in ALS. It will help to understand how changes in TDP-43 impact motor neuron survival. This information will be essential to develop effective therapeutics.
October 2019 - September 2024
The project aims to study people carrying genetic alterations that predispose to MND in the years before symptoms begin. By measuring the levels of thousands of proteins in cerebrospinal fluid – the fluid closest to the cells affected by MND – Dr Thompson aims to detect MND-related changes occurring in the nervous system long before the start of MND symptoms. This will hopefully shed light on the mechanisms that lead to the development of MND, paving the way for new therapies, and develop ways of predicting when MND will begin in order to allow earlier treatment of MND – even before symptoms develop.
April 2020 - April 2025
Our previous Clinical Research Fellows include:
Prof Martin Turner (University of Oxford) | August 2008 - July 2013 and August 2013 - August 2018
Dr Robin Highley(University of Sheffield) | February 2009 - January 2012
Dr Ceryl Harwood (University of Sheffield) | April 2009 - March 2012
Dr Pietro Fratta (University College London) | Sep 2010 - August 2013 and April 2015 - March 2019
Dr Johnathan Cooper-Knock (University of Sheffield) | September 2012 - September 2015
Dr Jemeen Sreedharan (University of Massachusetts Medical School and the Babraham Institute) | June 2013 - February 2018
Dr Jakub Scaber (University of Oxford) | August 2013 - August 2016
Dr James Bashford (King's College London) | October 2016 - September 2019
Dr Emily Feneberg (University of Oxford) | October 2017 - August 2019
An additional Clinical Fellowship was co-funded with MND Scotland and the Scottish Government Chief Scientist’s Office:
Dr Danielle Leighton (University of Edinburgh) | August 2015 - August 2018
The first Non-Clinical Fellowship was awarded to Dr Russell McLaughlin from Trinity College Dublin in 2016. The Non-Clinical Fellowships are funded solely by the MND Association.
Dr Bryson uses stem cells from mice transformed into motor neurones which will be used to create new muscle-neurone connections. These will be implanted back into the mice and observed for how well the neurones connect with muscles. The researchers will then identify the chemicals that promote successful innervation. This study has the potential to contribute to the development of a new therapy by replacing damaged motor neurones and restoring lost muscle function.
August 2017 - September 2021
An RNA molecule called NEAT1 forms the scaffolding of small compartments in a cell’s nucleus (the paraspeckle). It has been suggested the way NEAT1 is created may be altered and that these changes might be common to both sporadic and familial MND, and differentiate them from frontotemporal dementia. 'Dr Shelkovnikova's project will model changes in NEAT1 in neurones and observe how such neurones respond to stress and toxicity.
September 2018 - May 2023
A number of adverse processes in MND are caused by inadequate communication between two cellular structures – mitochondria and endoplasmic reticulum (ER). A lack of contact between these structures in certain types of MND can then lead to selective death of motor neurones. Dr Gomez-Suaga will investigate whether abnormalities in the C9ORF72 gene cause damage to the communication between mitochondria and ER, potentially establishing a target for intervention.
May 2018 - March 2022
Dr Wright will search for drug molecules that help SOD1 protein fold properly and create synthetic proteins that destroy misfolded SOD1 using the cellular recycling system. Ultimately, the project will help us understand what causes those instances of MND where SOD1 misfolding is present, and find new ways to remove it.
April 2019 - March 2023
Recently the team at the University of Nottingham discovered an interaction or ‘molecular handshake’ between TDP-43, a protein that builds-up and is toxic to motor neurones, and another protein called p62, which controls key cellular ‘waste-disposal’ systems. Preliminary findings indicate that this handshake could be harmful and in fact be responsible for the accumulation of ‘cellular waste’ that is commonly seen in affected individuals. Dr Scott will aim to understand the effect this dysfunctional interaction has on motor neurones, and will concurrently investigate the utility of targeting p62 to prevent the build-up of TDP-43.
August 2019 - July 2022
Preventing toxic protein aggregates being formed or preventing them causing damage are possible ways to treat MND, and the presence of these aggregates could be used for early disease diagnosis. However, detailed understanding of the shape, size and properties of these aggregates has been hampered by their low abundance and the fact they can form many different types of clumps. Therefore, it remains unclear how well the cellular models used in MND research best represent the real disease. This project will aim to use sensitive imaging techniques to enhance understanding of these aggregates.
TBC 2021 - TBC 2023
Healthy motor neurons work by transmitting signals from the brain and spinal cord to
muscles to allow us to move, speak and breathe. This relies on a complicated process known as ‘axonal transport’, which refers to the movement of important molecules up and down motor neuron cells. When people have MND, this transport process doesn’t work as well so the molecules that cells need to survive get stuck in the wrong places. Dr Tosolini’s research focuses on understanding this process, and how it might be restored in diseased human and mouse motor neurons.
November 2021 - October 2023
Development of ALS prognostic biomarkers based on patterned neural network dysfunction.
Our previous Non-Clinical Research Fellows include:
Dr Scott Allen (University of Sheffield) | January 2016 - March 2019
Dr Martina Hallegger (University College London) | January 2016 - December 2019
Dr Ashley Jones (King's College London) | March 2016 - August 2019
Dr Russel McLaughlin (Trinity College Dublin) | January 2016 - September 2019
Dr Matt Gabel (Previously University of Sussex, now at the University of Oxford) | July 2017 - June 2019