Award success for UK MND Collections

The MND Association has been awarded the prestigious 2019 UK Biobank of the Year Award.

Kirsten and Sarah with Biobank of the Year awardThe national accolade recognises the MND Association’s work on the UK MND Collections, previously called the UK MND DNA Bank – a resource of biological samples collected from people living with MND and controls between 2003 and 2012.

The award is in its fourth year and was presented by Amanda Gibbon, chair of the UK Clinical Research Collaboration (UKCRC) Tissue Directory and Coordination Centre Steering committee, and award sponsor, James Siddorns from Greiner Bio-One, at the UK Biobanking Showcase, held at the University of Nottingham in November.

The application process is coordinated by the UKCRC Tissue Directory and Coordination Centre, with a panel of Steering Committee members shortlisting the winning biobank and honourable mentions.

Case studies for two projects that use samples from the MND Collections were submitted as part of the application. The judging panel was particularly impressed by the number of samples that had been released to researchers as well as the research impact and evidence of wider collaborations and engagement. They also noted the readily available practical information contained within the MND Collections section on our website for researchers interested in acquiring samples.

Kirsten collects the Biobank of the Year awardUK MND Collections began in 2003. Participants had two blood samples taken alongside clinical information. One of the blood samples had DNA extracted and stored for genetic testing. The second blood sample had the white blood cells removed and stored in liquid nitrogen (a form of suspended animation) to act as a back up sample to replenish the stocks of DNA if they were ever to run out (see poster 1 about the use of DNA samples from the MND Collections).

As the study progressed researchers found that they were able to wake the blood cells up from their suspended animation and grow them in a dish to see the effect the DNA variations were having within the living cells.

Science has moved another stage further, and it is now possible to wake up these blood cells and persuade them to become induced Pluripotent Stem Cells (cells that can grow to make any other cell type within the body). These can then be converted into motor neurons in a dish. This enables researchers to see how the genetic variation in the DNA is causing the motor neuron to die as well as enabling the testing of potential drug treatments directly on the motor neuron (see poster 2 on the use of the cell line samples).

Dr Brian Dickie, the MND Association’s Research Director said:

“We are proud to receive the honour of being named the 2019 UK Biobank of the Year. The MND Collections continues to contribute towards the discovery of genes associated with MND, as can be seen from the announcement of a new gene on 25 November 2019. This award recognises the invaluable resource of biological samples that the MND Collections are able to provide to researchers around the world to help find the causes of MND and potentially a cure.”

The MND Association would like to thank all of the participants for donating the legacy of their time, blood samples and data, to all of the staff who worked across the many clinical sites to enable the collection of the samples and data and to all of the fundraisers who have raised the money to enable the MND Association to not only create this invaluable resource, but to help us continue to provide access to the samples and data to researchers around the world.

Find out more:

For further information and support contact our MND Connect helpline

mndconnect 0808 802 6262