Causes

These projects aim to understand the causes of motor neurone degeneration. This is essential to allow the development of treatments. Only by understanding what goes wrong in MND can scientists know how to design and where to target drug treatments. An asterisk (‘*’) next to a title marks the research projects that directly involve animals.

Biomedical projects

The UK Whole Genome Sequencing project (984-797)
Understanding and preventing the protein build-up that can cause cells to die (828-791)*
Validating and testing potential MND-causing genes (985-797)*
Using iPSCs to understand the interplay between C9ORF72 and TDP-43 (832-791)
Studying the detailed structure of SOD1 and TDP-43 (833-791)
Understanding how TDP-43 interacts with RNA to test new drugs (840-791)
Identifying genetic susceptibility factors in MND (844-791)
Investigating jumping DNA as a genetic risk factor for MND (843-791)
Gene-Environment database and analysis system (829-791)
Understanding and targeting autophagy in MND-FTD (845-791)*
Gene-hunting in Middle-Eastern MND cases (847-791)
Is reduced dynein function a cause and a risk factor of MND? (852-791)*
Utilising the C9ORF72 zebrafish model of MND to identify and validate a novel disease modifying therapy (854-791)*
Perturbation of the human itneractome by C9ORF72 repeat expansions: identification of pathogenic mechanisms and therapeutic entry points (856-791)
The role of axonal RNA transport in causing MND (857-791)*

Fellowships

Motor neurone signalling and the effects of RNA in MND (946-795)*
Identifying genetic causes of MND in specific populations (957-799)
Studying the role of TDP-43 mutations in the transport of RNA (959-799)
Understanding how MND alters the way cells generate and use energy (956-799)*
Using a new method to find rare MND-causing genes (958-799)*

PhD Studentships

The role of mitochondria in C9ORF72-related MND (870-792)
Using iPSCs to understand what happens to human motor neurones in MND (878-792)
Identifying changes in the brain tissue in MND and FTD (877-792)
Exploring the body’s defence machinery to tackle protein clumping (881-792)*
The role of glycospingo-lipids in MND (883-792)*
Using nuclear magnetic resonance to understand aggregation of TDP-43 (882-792)
Regulation of neuronal transport system by TBK1 and its relevance to MND (880-792)*
Using iPSCs to investigate mechanisms of toxic protein accumulation in C9ORF72-related MND/FTD (889-792)
Exploring the role of RNA processing and long gene regulation in ALS (885-792)
Understanding the role of Calcyclin in developing MND and Alzheimer’s disease (888-792)*

Last updated: 1 October 2017

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