The role of ALS-associated RNA binding proteins in axonal reinnervation and ALS pathogenesis

To investigate how protein production disruption, caused by FUS, can alter the function of nerve cells.

Nicol Birsa Consented Cropped Further

Lead Investigator: Dr Nicol Birsa

Lead Institution: University College London

MND Association Funding: £269,943* - Senior Non-Clinical Fellowship

Funding dates: September 2022 - September 2025

*Supported by the Lady Edith Wolfson Fellowship Programme

About the project

FUS is a protein that regulates the production of other proteins and is known to be dysfunctional in MND. This project aims to understand how the disruptions to protein production caused by FUS alter the function of nerve cells and their connection to muscles. Once it is understood how nerve cells are damaged, the project will move on to investigating if it is possible to correct this damage. Understanding the changes to nerve cells in MND is crucial to designing new and effective treatments.

What does this mean for people living with MND?

This project will help to understand how nerve cells are damaged in MND and then see if it is possible to correct the damage done. Understanding the biological mechanisms of MND is important to working out how to treat and ultimately cure the disease. This work will help to find new targets for therapeutic treatments.

Resources 

Want to find out more about the project and the researchers? Check out the resources below: 

Website:

Our Fellows | MND Association

Project code: 976-799