The impact of TDP-43 on translation and the response to axonal damage in Amyotrophic Lateral Sclerosis

The aim of this project is to discover how TDP-43 impacts a motor neurone’s response to damaged axons and how this implicated in MND.

Pietro Fratta

Lead Investigator: Dr Pietro Fratta

Lead Institution: University College London

MND Association Funding: £175,00* Clinical Research Fellowship

Funding dates: October 2019 - September 2024

* Supported by The Lady Edith Wolfson Fellowship Programme

About the project

TDP-43 is a protein important for the specific transport of RNA to different locations in the axons and in the response of cells to stress and damage. This project will combine novel mouse models and patient cell lines to investigate how TDP-43 impacts the response of motor neurons to damage in the axons, and the relevance of this response pathway in ALS. It will help to understand how changes in TDP-43 impact motor neuron survival.

What does this mean for people living with MND?

Discovering how faulty TDP-43 proteins, a hallmark of MND, are implicated in the disease will deepen our understanding of the underlying neural mechanisms which contribute to disease onset and progression. This information will be essential to develop future effective therapeutics.

Resources 

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Website:

Our Fellows | MND Association

Project code: 951-795