Developing strategies to promote muscle reinnervation in MND

To develop a new strategy to create new connections between motor neurons and muscles using stem cells

Barney Bryson Lab April 2021 (consented)

Lead Investigator: Dr Barney Bryson

Lead Institution: University College London

MND Association Funding: £286,079* - Senior Non-Clinical Fellowship

Funding dates: August 2017 - July 2022

*Supported by The Lady Edith Wolfson Fellowship Programme

About the project

This project uses stem cells from mice transformed into motor neurons which will be used to create new muscle neuron connections. These will be implanted back into the mice and observed for how well the neurons connect with muscles. The researchers will then identify the chemicals that promote successful innervation. This study has the potential to contribute to the development of a new therapy by replacing damaged motor neurons and restoring lost muscle function.

What does this mean for people living with MND?

This project could lead to the identification of new therapeutic strategies which may prevent the breakdown of the specialised connections between motor neurons and muscles in those with the disease.


The senior non-clinical fellowship has been a tremendous springboard to not only drive my research project forward but, importantly, it has also set me on the path towards a fully independent research career. I have received incredible support from the Association throughout the duration of my Fellowship [...] Most importantly of all, the generous support from the MND Association has enabled me to make great strides in advancing an extremely exciting and novel therapy aimed at overcoming list muscle function for MND patients.


Project code: 965-799